McCormick School of Engineering
Department of Chemical and Biological Engineering
The Shea Lab works at the interface of regenerative medicine, biomaterials, and gene and drug delivery. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation or promote regeneration. Of particular emphasis in the lab is:
- Identifying the fundamental design parameters for delivery of gene therapy vectors from biomaterials. We investigate strategies based on either sustained release approach or surface immobilization (i.e., substrate mediated delivery). These design parameters provide a fundamental tool for numerous applications.
- Applying the controllable microenvironments to in vitro and in vivo models of tissue formation, which includes ovarian follicle maturation, nerve regeneration and islet transplantation.
- Developing diagnostic assays for cancer research using the fundamental tools of gene delivery from biomaterials.
- Congratulations to Anaar Siletz on the acceptance of her manuscript entitled "Dynamic Transcription Factor Networks in Epithelial-Mesenchymal Transition in Breast Cancer Models" to PLOS ONE.
- Congratulations to Jack Graham on the acceptance of his manuscript entitled "PLG Scaffold Delivered Antigen-Specific Regulatory T cells Induce Systemic Tolerance in Autoimmune Diabetes" to the journal Tissue Engineering!
- Congratulations to Stephanie Seidlits and Michael Gower for the acceptance of the manuscript to Expert Opinion on Drug Delivery.
- Congratulations to Aline Thomas on the acceptance (virtually) of her manuscript entitled "Bridges with high channel density, porosity for enhancing axon growth after injury" to the journal Biomaterials.