McCormick School of Engineering
Department of Chemical and Biological Engineering
The Shea Lab works at the interface of regenerative medicine, biomaterials, and gene and drug delivery. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation or promote regeneration. Of particular emphasis in the lab is:
- Identifying the fundamental design parameters for delivery of gene therapy vectors from biomaterials. We investigate strategies based on either sustained release approach or surface immobilization (i.e., substrate mediated delivery). These design parameters provide a fundamental tool for numerous applications.
- Applying the controllable microenvironments to in vitro and in vivo models of tissue formation, which includes ovarian follicle maturation, nerve regeneration and islet transplantation.
- Developing diagnostic assays for cancer research using the fundamental tools of gene delivery from biomaterials.
- Congratulations to Jia Wu and Seungjin Shin on the acceptance of their manuscript titled "Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation". Other collaborators include Professor William Miller, members in his lab, and Professor Neda Bagheri.
- Congratulations to Kelan Hlavaty on the acceptance of her manuscript titled "Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds" to the American Journal of Transplantation.